邢唷>? ?欹€ 餜秱bjbjqq<ee?mRR8T;[&z:Q^$????????w+d?-MQ?4&W W W &?W ?W W :"b"燖阚GR"?+&0[&Z"??b"b"?v"\W ??n[&?R a: D桍N1縺$v鴙sQ亃豐鶺郪纇Km諎BR貧愊慘m廭誰 '`齹膵鱊?u鑜孮€b/g錱c黐烻R,gc黐烻R鑕(Wc黐鑜孮3u鲖篘鵞縺$v鴙sQ鶺郪纇Km諎BRR恎'`齹膵鱊鑜孮3uD崣e剉芉Y蔛癲橯  T鰁_N:N€b/g膵钀钑鵞鑜孮3uD崣e剉€b/g膵衏汷耂€0,gc黐烻R/f垟鵞縺$v鴙sQ鶺郪纇Km諎BRR恎'`齹膵鱊剉N,倎塀l 3u鲖篘擽漁nc罷剉wQSOyr'`nx歔vQ-N匭筟/f&T?u 鍌N?u 梬QSO栶t1u蔛鴙擽剉褃f[漁nc v^漁nc罷剉wQSOyr'`鵞鑜孮3uD崣e剉匭筟蹚L圗Q瀃孴苸S0,gc黐烻R/f鵞3u鲖篘孴錱篘XT剉c黐'`噀鯪 FONS靊鑜孮yb@b塵蔛剉L?e婲y N\O:N誰膲:_6RgbL 俌済 g齹Y醤硩鴙sQ誰膲亯Bl剉vQ諲筫誰 _N颯錘菓(u FO梺夋嬈~ft1u v^鵞vQ褃f[Tt'`蹚L垖毩 衏汷鎷苸剉xvzD崣e孴寶翄D崣e 鴙sQ篘XT擽(Wu惇_鴙sQ誰膲剉MR衏 NO(u,gc黐烻R0,gc黐烻R/f(W皊L堈l膲孴h芉SO鹼錘蔛S_MR鍂4ls^ N6R歔剉 彇@w誰膲孴h芉剉N璭孾刄 錘蔛褃f[€b/g剉N璭裇U\ ,gc黐烻R鴙sQ匭筟_N\愽e蹚L宼e0N0?u凈V,gc黐烻R@b饛縺$v鴙sQ鶺郪纇Km諎BRR恎'`齹膵鱊;N亯/fc鶺嶯貧愊慘m廭high-throughput sequencing sS NN鉔Km廭next generation sequencing NGS  萐饄:N'Y膲!js^L圞m廭massively parallel sequencing MPS  SOY纇Km篘SO膥莮縺$v苸迉-N剉縺$v鴙sQ鶺郪豐_0(u嶯纇KmSO苸迉亃豐剉NGSck(W^踠(u嶯縺$v蕥梪鴙sQ剉RP[纇Km S靊鵞yr歔鶺郪剉DNA/RNA蹚L圞m廭 錘鸞~bN縺$v4N奮蕥梪鴙sQ剉鶺郪豐_0縺$v鶺郪亃豐{|媁S靊筽亃豐0襝eQ0:1Y0鶺郪蛻抍0鱞峱e_8^I{^IN剉鶺郪亃豐0鶺嶯NGSKm廭烻t剉SOY蕥璭In Vitro Diagnosis IVD 纇Km颯齹S靊錘 Nek7h,g6e茤0Yt孴軴X[08hx懶c諷蔛Yt0噀揯6RY0Km廭孴眡鶺茓+R0廭R詋鵞0豐_茓+R孴菑鋘0豐_鑜蕬孴銐麐錘蔛纇KmJT剉ub0 T鰁 術汵罷貜颯齹OS靊o忲N钀R FO N饛鴙sQekv^NN歔珗hQ钀S靊 擽9hnc罷剉wQSO緥Am zeg蹚L?R璭0鵞嶯蟢*N纇Kmek 3u鲖篘梺売~T罷緥孴4N奮aINeg鷁藌yr歔剉颯譙剉(嵪懩嬿Nch孴TfP[纇Km0縺$vhQ鶺郪膥Km廭0蜰4YKm廭08n粂DNA纇Km0RNA魐Km廭0舥烻SO甠uir蔛廩鶺郪膥f[Km廭0趢蝷ieQMR纇Km0緐舥螛i+TW O螛i 膵0ON剺Km0魐bT坢9€Km廭蔛eP穅篘[{錱0孨0NGS'`齹膵鱊N 鼅饛D崣e鼅饛D崣e;N亯S靊罷剺g(u0罷蟘饛0 gsQuir塠hQ'`剉魦f0xvz觺済剉;`觺膵鱊錘蔛 T{|罷 N^臽礠薔蛜I{匭筟0 3u鲖篘(WR_裇N*N g垟鵞'`剉鶺郪纇Km諎BR鰁 梟x歔vQ剺g(u0卂Km鶺郪pe蠎0纇Km亃豐MO筽b€亃豐{|媁 S靊\亯纇Km剉7h,g{|媁0?u篘錘蔛闠汵{|媁剉纇Km酧o`\珗膵0O孴JT0貜擽€Q唓_蚑纇Km剉緥0寶翄孴(嵪懅c6R剉vQ諲郪 } v^(W諎BR膥b魦ffN-N鎷苸魦f鍕罷S+T剉諎BR膥R蔛梺塅O*g衏汷剉諎BR0緥Y蔛€Pg0\O:NIVD纇KmN,偀SR 3u鲖篘擽枡HQ歔IN3u罷剉剺g(u悓T纇Km'`齹 罷剉剺g(u\魐q_蚑纇Km緥孴纇Km'`齹錘蔛Km廭孴/bJT剉鶺郪{|媁03u鲖篘梺塎R粀'`0Wnx歔擽蹚L垊vxvzch婳俌芉nx'` 錘蔛蟢蛓xvzch擽鍕醤硩剉h芉0(W緥孴_裇孾bKNT 寶翄xvzvQ/f&T醤硩剺歔IN剉'`齹0俌済纇KmN&{T鸑UO剺歔IN剉'`齹h芉 R擽R恎烻郪0蛻癳寶翄b頞9e剺歔IN剉'`齹ch0惽復SY剉緥0_裇孴寶翄 魐0R纇Km醤硩緥歔桞l0(Wte*N菑 z-N3u鲖篘梺壈婾_@b gxvz筫Hh0xvz菑 z孴觺済錘蔛蟢yxvz緥剉t1u0鷁畫3u鲖篘R鶴7h,gYt0噀揯6RY0Km廭0u酧R恎I{痵倐;N亯(嵪懅c6R耂pe0俌噀揯Sm蔛Gr祂暒^0眡鶺茓+R(嵪慄PBase Call Quality scores 0菑鋘T gHeReadspe0 gHeKm廭駇俌蟸菑籗蛻YtI{ 0&{TgNOKm廭駇孴s^GWKm廭駇亯Bl剉:S遅% I{03u鲖篘擽衏汷te*N纇KmAm z剉h芉蚫\O z廭噀鯪Standard Operating Procedure SOP  鵞NGS€b/g纇KmhQ菑 zS靊剉7h,g6e茤Yt0噀揯6RY0Km廭0pencR恎0觺済JTI{菑 z蹚L埾c饛0uir酧o`f[R恎筫b椣c饛孴皨U_pencYt孴R恎 S靊豐_茓+R0菑鋘孴鑜蕬剉@b g菑 z0fnx@b g亯O(u剉o忲N S靊eg恘婳俌匭钀_裇錘蔛,{ N筫 錘蔛;N亯頞9e0鷁畫錘Rh坆__蟘饛@b g梺墑vo忲N孴/bpenc揯T饄0Hr,g蔛vQ烺齹0孨 ;N亯烻Pg檈剉xvzD崣eNGS纇Km菑 z;N亯S靊7h,g6e茤Yt0噀揯6RY0Km廭0pencR恎0觺済JTI{01.7h,g6e茤Yt俌?u 7h,g6e茤Yt菑 z/f軴翄7h,gwQ g齹俌瀃蚐 f€SO乢剉sQ.暞s倐03u鲖篘椥c塵蔛7h,g6e茤蔛Yt鴙sQ諎BR;N亯烻Pg檈酧o` 俌7h,gMRYt諎BR07h,g袕搹軴X[諎BR08hx懶c諷諎BR剉;N亯膥bbRI{02.噀揯6RY蔛Km廭Km廭噀揯刧鷁蔛Km廭菑 z-N@b椪婤R;N亯S+T1?l8h謡8h鱾 N鱴x0迯v0Z€Tv0恖廢_v0P?R'`匭Rv0_ir0垟04YI{俌:N3u鲖篘陙Lxvz剉;N亯烻Pg檈 3u鲖篘擽鵞Km廭噀揯刧鷁剉瀃寶菑 z圢錘鎷饛v^衏汷鵞T;N亯烻Pg檈剉烺齹'`xvz0v^鵞6RY孾b剉烻檈b罷蹚L?嵪懤h寶錘nxvQ&{Th芉亯Bl Nte*Nu錧z倲^3z歔颯0俌:N3u鲖篘Y-崉v;N亯烻Pg檈 擽鎷饛蟢N蛓烻Pg檈Y-嵐eeg恘 衏Y-嵐e鶴wQ剉蟢蛓烻Pg檈'`齹ch蔛(嵪懅c6RD崣e v^鎷饛3u鲖篘鵞Y-岥N亯烻Pg檈剉Tch(嵪憗塀l錘蔛nx歔鍕烻Pg檈\O:N,g罷;N亯烻Pg檈剉鎷苸漁nc08hx憑|纇Km諎BR剉S艌Pg檈孴€Pg擽鄀1?l8h謡8hx憊Deoxyribonuclease,DNase 孴8h謡8hx憊Ribonuclease RNase al觛03.uir酧o`R恎蔛penc揯亯BlNGS剉pencR恎Am zbuir酧o`f[Am zN,傦S錘R:N眡鶺茓+R0廭R詋鵞0豐_茓+R孴豐_鑜蕬I{0fnx耂€廭R{|媁 N T亃豐{|媁颯齹梺_裇N T剉豐_/亃豐纇Km梴誰0vQ!k 擽9hnc罷緥{|媁衏汷o忲N錧wQ剉凈V孴@b梽v寶翄{|媁0俌塵蔛penc揯O(u 鷁畫3u鲖篘衏penc揯剉痭恘酧o`0penc揯{|媁0孾te'`0瀃鰁'`0魚錘蔛R恎o忲N剉Hr,g0'`齹寶翄I{D崣e04.耂€罷亯Bl匭钀耂€罷/f軴翄罷'`齹3z歔'`錘蔛纇KmfW?N奮aINb\o(W4N奮aIN剉鶺郪 擽€Q嗐Nh?`顣槝 fnxwQ g4N奮蕥璭aIN剉鶺郪{|媁蔛鶺郪媁-NN T剉豐_{|媁0亃豐憳噑0豐_{|媁剉 愔S擽wQ g鉔h?` S靊N TY>fP[ N T鶺郪豐_亃豐I{0俌纇Kmx:S儚'YNX[(W^楉p筽:S遅緥俌'Y嶯1M  鷁畫(W3?`耂€罷-N€Q嗼[纇KmteSO:S遅剉upOe寶翄;N亯sQ鑜SNVI{  俌鱩T剉8luSck8^篘}v苸迉DNA≒X[瞞I{0N T亃豐/豐_剉豐_0N蔛亃豐憳噑 Sm凈V緥n擽wQ g鉔h?`v^衏汷購7h緥歔剉漁nc03?`耂€罷剉亃豐b__蔛鱞峱e椙?u gHe筫誰蹚L坣x v^fnx譙h芉03u鲖篘(W緥3?`耂€罷鰁颯Nv^€Q喞hKmP柭S€罷剉緥n蔛nx筫_ v^衏汷鴙sQ剉漁nc04.1.23?`(崸c罷!j遙舥篘7h,g剉顅h8hx憦^R v^(u嶯(崸cte*N纇Km菑 z S靊8hx懶c諷俌?u 0噀揯刧鷁0Km廭孴pencR恎0顅MR3?`(崸c纇Km孴R恎菑 z擽N4N奮7h,g筫_N魜04.24?`耂€罷蔛4?`(崸c罷4?`耂€罷蔛4?`(崸c罷鷁畫:Nck8^4N奮7h,g剉鱩Tirb苸迉鹼 擽fnxN+T g顅h:S遅縺$v亃豐鶺郪04.3緗芠耂€罷緗芠耂€罷緥n亯Bl颯耂€3?`/4?`耂€罷04.4 PCR 諎BR鄀!jg(崸c罷No Template Control NTC 俌?u 3u鲖篘擽9hnc3u罷yr筽緥nNTC(崸c罷蔛纇Km譙h芉 裿Km纇Km菑 z-N/f&TX[(Wal觛0  N ;N亯u錧z偸S蚐擽SO鹼剉xvzD崣eNGS纇Km/fN*NYBg剉錧\OAm z 僛1u坃Y靣藌ek膥T €b0N, € 鵞嶯蟢*N纇Km膥b钀R 3u鲖篘擽鷁藌vQyr歔纇Km剉ch孴寶6eh芉0臺{橓[NGS蟢*N蚫\OAm z剉'`齹h埌s蹚LN*N匭钀剉寶翄0蟢ekAm z龕梺R+ROS0RN*NgsO蟸寶

~z:<`b( 熨烊烊烊旄飓灀唘萣萉萉渠%h?%h?%B*CJ KHPJaJ ph!h?%h?%B*CJ PJaJ ph%h?(h怐@堹B*CJ PJaJ ph!h?%h怐B*CJ PJaJ phh?%h怐CJ PJaJ h?~CJ PJaJ o(h?%h怐CJ PJaJ h?%hTCJ PJaJ h鉳B*CJ KHPJaJ ph!h?%h怐B*CJ PJaJ ph%h鱩h怐B*CJ KHPJaJ ph%h?%h怐B*CJ KHPJaJ ph "X~ ???X$Z$t$%|&?*,*?熨熨熨熨烊啡啡啡烊啡泿泏鞗靘XmX( *h鱩h怐B*CJ KHPJaJ ph *h鱩h怐CJ PJaJ %h?%h怐B*CJ KHPJaJ phh齁GCJ KHPJaJ o(h?%h怐CJ KHPJaJ h?%h怐CJ PJaJ !h?%h?%B*CJ PJaJ ph!h?%h怐B*CJ PJaJ ph%h?%h?%B*CJ KHPJaJ ph%h?%h怐B*CJ KHPJaJ ph!8LXhh x h! "?p#Z$p$%&%???$&|&??J(剙d旋WD`剙gd?(剙d旋WD`剙gd?(m$J(,)*,*^+??r-?@.f/z/133f4?P6779?L;4<命剙d潺WD`剙gd鬋Om$剙d昌WD`剙gd鬋Om$剙d旋WD`剙gd?(m$???F-?>.??56989B9H9锄怔?羸啁F<H<近咙拯?(=稞觚N哠樵皆樵獨埅x猠猈猠xUU *h鱩h怐CJ PJaJ $ *h鱩h鉳B*CJ PJaJ ph *h鱩h怐CJ KHPJaJ " *h鱩h齁GCJ KHPJaJ o( *h鱩h齁GCJ KHPJaJ $ *h鱩h怐B*CJ PJaJ ph, *h鱩h怐@堹B*CJ KHPJaJ ph( *h鱩h怐B*CJ KHPJaJ ph+ *h鱩h齁GB*CJ KHPJaJ o(ph命(=B=觚0N琋襈濷癘^P|P郠XRfRzR圫糢篧糤網$dp$Ifa$gd?($?d旋`?a$gd?(剙d旋WD`剙gd鉳剙d旋WD`剙gd?(剙d旋WD`剙gd?(m$1.6 NGSpenc剉X[≒0 O搹NqQ玁俌?u (u嶯≒X[烻薡孴蟸菑R恎T剉纇Km觺済0鷁畫3u鲖篘衏pencX[≒-N胈剉塠hQ'`03z歔'`0魚NGS筫Hh錘蔛_8^臽礠Yn筫HhI{D崣e01.7lQqQ/匭钀penc揯擽(u俌?u 俌3u罷剉Km廭觺済梺P㏑lQqQ/匭钀penc揯蹚L堄~済鑜蕬bJT銐麐 3u鲖篘椥c汷@bO(u剉lQqQ/匭钀penc揯(W罷纇Km-Nw?R剉\O(u魦f lQqQ/匭钀penc揯{|媁0烺齹薔蛜0Hr,g鱏0h芉蚫\OAm z蔛(嵪懅c6R筫HhI{02.;N亯'`齹chR恎'`齹寶翄S靊惽N膥剺歔IN'`齹膵鱊筫_ 錘翄f'`齹/f&T硩錘醤硩vQ剺g(u恦^&{T剺歔IN剉'`齹h芉0?^塵蔛/f&T&{T邁f[膵鱊亯Bl b纇Km/f&TX[(WN€剉緐舥鴙sQ剉豐_I{02.1R恎'`齹(u7h,g緥n亯Bl3u鲖篘擽衏汷(u嶯膵0OTy?`齹xvz剉h,gpe蠎孴{|媁緥歔剉漁nc09hnc罷剺g(u 7h,gxvz擽S靊鉔h?`豐_孴豐_{|媁0xvz擽€QN纇Km悢^莡鴙sQ剉4N奮aIN:S遅 鑽N T鶺郪:S遅剉豐_0緰錘Km廭b緰錘詋鵞剉鶺郪:S遅 篘錧鱩TL]TSO錘蔛鸑UOvQ諲豐_{|媁0纇Km:S遅0婳俌俌済纇Km鑕(W(u嶯纇Km孴JT襝eQ0:1YMO筽I{ 擽S靊FONP枎NN T'Y\剉鶺郪Gr祂0亃豐@b(W:S遅I{0擽(Wxvz-NO(u+T gN纇Km悢^莡鴙sQ剉4N奮7h,g 4N奮7h,g擽wQ g怱_剉鉔h?` nx軴颯唹講3u罷餢饄剉4N奮鴙sQ廭R豐_I{02.2芉nx'`2.2.1;`SO亯Bl芉nx'`S靊鵞詋纇Kmy 2018.122.媠鸰(t.癳N鉔Km廭pencR恎 褃f[鶴Hr>y 2018.23.Stuart M.Brown.,{孨鉔Km廭酧o`Yt 褃f[鶴Hr>y 2017.14.ek廩0鯯0NI{.4N奮RP[舥tNGS100顣€{f顣T{,{NHr 5.-N齎邩罷o兞T纇歔xvzb ,{孨鉔Km廭€b/g纇Km諎BR(嵪懩嬿N?u€b/gc黐烻R6. EVALUATION OF AUTOMATIC CLASS III DESIGNATION FOR MSK-IMPACT Integrated Mutation Profiling of Actionable Cancer Targets 7. The Association for Molecular Pathology American Society of Clinical Oncology,and College of American Pathologists Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer The Journal of Molecular Diagnostics Vol. 19 No. 1 January 20178.Verification and Validation of Multiplex Nucleic Acid AssaysApproved Guideline. Clinical and Laboratory Standards Institute. NCCLS MM17-A Vol.28 No.9 ISBN 1-56238-661-109.Guidelines for Diagnostic Next-Generation Sequencing. European Journal of Human Genetics 2015 241 1584-1589010.ACMG Clinical Laboratory Standards for Next-Generation Sequencing. Genetics in Medicine 2013 159 011.Ewing AD Houlahan KE Hu Y Ellrott K Caloian C Yamaguchi TN Bare JC P'ng C Waggott D Sabelnykova VY et alCombining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection. Nature methods 2015 127 623-630.12.FDA.Considerations for Design,Development and Analytical Validation of Next Generation Sequencing NGS  Based In Vitro Diagnostics IVDs Intended to Aid in the Diagnosis of Suspected Germline Diseases13.FDA.Use of public human genetic variant databases to support clinical validity for genetic and genomic-based in vitro diagnostics Document issued on April 13 2018.14. FoundationFocus"! CDxBRCA Technical Information Summary15.-N齎縺$vq毃R鶺郪R恎T€遶CAGC  -N齎4N奮縺$vf[OCSCO 孨鉔Km廭NGS €b/g擽(u嶯4N奮縺$v緗芉;Sf[蕥璭剉qQ茓,{NHr諎L 2016.04.2316.-N齎4N奮縺$vf[O縺$vh譥irN禰訷XTO -N齎縺$vq毃R鶺郪R恎T€遶孨鉔Km廭€b/g(W縺$v緗芉;Sf[蕥璭-N剉擽(uN禰qQ茓 -NNS;Sf[Bg譥9826 2018.7.10擭0w岻僓SMO齎禰o兞T裿cwt@\;S梪hV癶€b/g膵-N胈0  PAGE \* MERGEFORMAT16   PAGE \* MERGEFORMAT17   PAGE \* MERGEFORMAT1哠圫頥餠NWPW刉圵篧蜽蠾釽鋀XXX XHXJX@YVYjYlY~Y€Y燳篩糦郰釿ZZ躘胴呢呢呢睘嬝嬝嬝嬝嬝x瀷貗貗貗貗貗豤( *h鱩h怐B*CJKHPJaJph$ *h鱩h怐B*CJPJaJph$ *h鱩h怐B*CJPJaJ ph$ *h鱩h怐B*CJPJaJph$ *h鱩h怐B*CJ PJaJ ph' *h鱩h齁GB*CJ PJaJ o(ph$ *h鱩h怐B*CJ PJaJ ph' *h鱩h疧JB*CJ PJaJ o(ph#網萕蜽蠾襑訵赪郬釽Gkd$$IfT杔4斊謀?< 5 €Q t?644 layt?(奣$dp$Ifa$gd?(釽鋀頦鬢鳺黈C4444$dp$Ifa$gd?(kd$$IfT杔4斊謗?< 5 €€ t?644 layt?(奣黈XXXXX4kd$$IfT杔4斊謗?< 5 €€€€ t?644 layt?(奣$dp$Ifa$gd?(XXX X"X(X4kd]$$IfT杔4斊謗?< 5 €€€€ t?644 layt?(奣$dp$Ifa$gd?((X0X8XHXJX6kd$$IfT杔斊謗?< 5 €€€€€ t?644 layt?(奣$dp$Ifa$gd?(JX@YVYXYZYdYjY$dp$Ifa$gd?($?d旋`?a$gd?(?d旋WD`?gd怐jYlYnYpYvY|Y~YTEEEEE$dp$Ifa$gd?(kd$$IfT杔4斊謀?5 h€]  t?644 layt?(奣~Y€Y奩怸擸榊A2222$dp$Ifa$gd?(kd$$IfT杔4斊謗?5 h€€ t?644 layt?(奣榊燳猋甕2kd$$IfT杔4斊謗?5 h€€€€ t?644 layt?(奣$dp$Ifa$gd?(甕瞃篩糦綴衁2kd$$IfT杔4斊謗?5 h€€€€ t?644 layt?(奣$dp$Ifa$gd?(衁訷豗郰釿鋂2kdk$$IfT杔4斊謗?5 h€€€€ t?644 layt?(奣$dp$Ifa$gd?(鋂闥鯵ZZZ3kdM$$IfT杔斊謗?5 €h€€€€ t?644 layt?(奣$dp$Ifa$gd?(Z郲鳾猏竆._H_鎋鴂朻襛郺c渃fd恉&fBf╢詅dhrh鎖緅剙d旋WD`剙gd怐剙d旋WD`剙gd怐m$?d旋WD`?gd怐m$躘郲猔琡6btb`cbcfd俤刣哾宒巇&f╢甪h"hdh4i6i鎖Tjrktkvk€k熨荣纲椯囐嚄贄葁荣荣萪Q%h?%h怐B*CJ KHPJaJ ph%h?%hTB*CJ KHPJaJ phh齁GB*CJ PJaJ o(phh鉳B*CJ KHPJaJ phh?%h怐CJ KHPJaJ "h齁GB*CJ KHPJaJ o(phh齁GB*CJ KHPJaJ ph!h?%h怐B*CJ PJaJ ph%h?%h怐B*CJ KHPJaJ ph%h?%h怐B*CJKHPJaJph緅tk俴Bl謑緈俷頽"olo秓.p爌蕄 q8r宺,s|s妔膕$剙d旋WD`剙a$gd?( 剉d旋`剉gd鍳3d旋gd怐剙d旋WD`剙gdv[u剙d旋WD`剙gd?(剙d旋WD`剙gd怐€k俴妅宬纊耴膋@lBlPl詌謑辧鄉mm糾緈膍趍n nBnDn坣妌攏鰊o(o*o:o{P{R{襻襻襻裎花槰槰槰槰槰槰嚚槰槰槰槰槰槰槰槰槰槰槰槰槰槰!h鉳CJ OJPJQJ^JaJ o(h鉳CJ OJPJQJ^JaJ $h?%h怐CJ OJPJQJ^JaJ %h?%h怐B*CJ KHPJaJ ph%h?%hTB*CJ KHPJaJ phh?%h怐5丆J KHPJaJ h?%h怐CJ KHPJaJ 5膕Nt巘趖評鷚Ty6z{}殈^€爜畞貋趤迊鄟鋪鎭陙靵 $d旋a$gdv[um$剙dWD`剙gd?($剙d旋WD`剙a$gd?(R{d{f{~{€{巤恵渰瀧皗瞷趝躿鄚鈢鎩鑭陓顋X}Z}蕔蘿襺詝謢~~~~爜瑏畞謥貋趤軄鄟鈦鎭磔磔磔磔磔磔磔磔磔磔磔磔薯蓓蓓蓓蓓桨媬vrvrh鴒(jh鴒(Uh?%hyFCJPJaJh?%hTCJ PJaJ h?%h鍳3CJ PJaJ h疧JCJ PJaJ o(h?%h鍳3CJ PJaJ h?%hTCJ PJaJ $h?%h怐CJ OJPJQJ^JaJ h鉳CJ OJPJQJ^JaJ $h?%h怐CJ OJPJQJ^JaJ ,鎭鑱靵顏騺魜鴣鷣$&*,.0246:<fhlnrtvxz|▊獋瑐皞矀磦秱黧黧庵羌仟侵灱殩智记肘紡媰僸m骮h?%hyFCJPJaJhYh疧Jh疧JmHnHsHuh疧Jjh疧JUhv h淣h淣h zh)h鉳h疧JCJaJo(#h h CJaJmHnHsHuh?(h疧JCJaJjh?(h疧JCJUaJh?(h疧JCJaJo( h?(h疧JB*CJaJo(phh鴒(jh鴒(U$靵饋騺246vxz畟皞矀磦秱 $d旋a$gdv[um$$a$ $4$a$gd淣 $4$a$gd?(刪]刪gd淣:&P 1?2P:p?(皞. 捌A!胞"胞#悎$%癝斑 惄$$If!vh555Q5#v#vQ#v:V 杔4斊 t?6+++,55Q5yt?(奣$$If!vh55555#v#v:V 杔4斊 t?6+++,55yt?(奣$$If!vh55555#v#v:V 杔4斊 t?6+,55yt?(奣$$If!vh55555#v#v:V 杔4斊 t?6+,55yt?(奣$$If!vh55555#v#v:V 杔斊 t?6,55yt?(奣$$If!vh5h55] 5#vh#v#v] #v:V 杔4斊 t?6+++,5h55] 5yt?(奣$$If!vh5h5555#vh#v#v#v:V 杔4斊 t?6+++,5h555yt?(奣$$If!vh5h5555#vh#v#v#v:V 杔4斊 t?6+,5h555yt?(奣$$If!vh5h5555#vh#v#v#v:V 杔4斊 t?6+,5h555yt?(奣$$If!vh5h5555#vh#v#v#v:V 杔4斊 t?6+,5h555yt?(奣$$If!vh5h5555#vh#v#v#v:V 杔斊 t?6,5h555yt?(奣b 002 0@P`p€2( 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€8XV~PJ_HmH nHsH tHJ`?J ck噀 $1$a$ CJKH_HaJmH nHsH tH$A ?$ 貫祂=刉[SOBi@?B nf恏圏h4 l4a k ? 鄀Rh 8Y8 =噀ch觺刧-D M €.. yb鑜Fh噀,gCJaJH `H )0u$9r G$a$CJaJmHsHtH)! )uxZ 2Z  ]0u w'$9r &dG$Pa$CJaJmHsHtH2??A2 淣0u w Char CJKHaJ2??Q2 淣0u Char CJKHaJh?bh 怐Default1$7$8$H$1B*CJOJQJ^J_HaJmH nHphsH tHPK!倞[Content_Types].xml瑧薺?E鲄卸豶?ヘ微Iw},浔-j弰4 蛇w旄P-t#b螜{U畯銧擉T閁^h卍}悒)蛔*1P? 揯鬃W孱0)櫐T闉9<搇?ぼ$yi}佸;纞@囨?顚跄H滖男u? D谞z內/0娗盃瘥 $€ X3aZ⒁锣,癉0j~?叨蝏沩~i>赝3縗`??[G殁\??跼k.搒粣..椃碼婵?PK!ブх6 _rels/.rels剰蟡? 囷吔冄}Q颐%v/C/?h"脎O 劋秣?孂釘 毆免C?薶醰=偵叅?[xp啠{鄣_糚眩秣羌3緓镹男>掤搁U蟇L0斈屵呖z迃rx鳔脅稔h9T?奣/魁煜?鍃Y?雒'蟸?S琦棌~蜩鶅O_|w?馉镉圚t燒乤?d NG1-Rl苼?諶J鴚T锠疢1Kｃ柩"o he浪撣幝絇L-憒%绗臙甴Y7?qP.\L姼=岟薲穛炷?I爋fi墸?帽墘BRb?J款P_p蒅 茛▍i㎏鷗郿訉h汧梚櫷o?;7Q嫵2染媱珼?a/銐翾漱嶺厌W 藬霱卂膗H剄)薶 胺?:Vi豾?r態裶汐橌"r嫃?帓2l徠a麃C奲此U|嚮!8^顩?帼軤仯?A魶壭眲V韙鄨讕厏ls囔?4犁_=,涩返o聻TV 跥陲"苎鎎H唼灮???熯x薜躻-戏蹺鮸褾;氕衯踯`嘼3"G 'e\昮H柊O 话ㄩ恬愪'?劘i_wp伬 ??靺8魂i&丩Y%\铝?楎謝視=瞩伭壵阱綔 r6f 提3储淭厥厰)橗:陋ZK誏玸ゅ&C 鏜兣軟0€ [浪玴@注醏j扣? 媺耏咹唜Hi荤cT5A蕆跑@顢腍驇馴AZC硙i' RQ\m伕,zo?僩Q襲{Y\,Nψ?铸溷ら嵿L _?跆嘫7C6韽-fS宄h62密"5咍麥罭H凾[X?5太4X?Y龡豚殖2纅鷎h辈绅痠~tCKF#猥b +趙?m鑵4`眹!?U翞!昿5a:倊€{4韒笫m蝘o 萎c杽8m泛D矹秔S枪姗豓1铘?#S奿?3E?pS?疳W`る甸q]( ┻08樲w别 n撏A鲺[s枃)k8皓= Aa?R d趻删c楿咏瞬d)#換ueb恾满捷C!ず?i0福>4魫S?鋥z虮 F箎 4?sKvUKo瘸椒h垀1砵YU€奥V蠬塔5U8錠k;譁潘鮈9堚寂皹D 荀 ?*|FL迪鳡?A3兇伂>g类dm2iV值殍そ杕謌<殒r?[kv抶熞蠃p鎶sj?潩z伛礭[鑚堨叆Qv??縤u鈨?高?%M2羙J描?u舘%覎PK!褠煻'theme/theme/_rels/themeManager.xml.rels剰M ?匃倃oo雍?輬协勪56?$Q祉?.嘺緳i粭澤c2?h:闀q毩m胳嶡RN壻;d癭値o7g慘(M&$R(.1榬'J摐袏T鶂?V?＆A然蠬鱱}狇|?絙{朠?除8塯/]As賲(⑵锑#洩L蔥汉倪PK-!倞[Content_Types].xmlPK-!ブх6 +_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!mQtheme/theme/theme1.xmlPK-!褠煻' theme/theme/_rels/themeManager.xml.relsPK] V5  .PPlo&?哠躘€kVqR{鎭秱!"%BPRSUVJ(命網釽黈X(XJXjY~Y榊甕衁鋂Z緅膕靵秱 #$&CDEFGHIJKLMNOQTW%(0FIPfho!?晙!?晙!?晞餈  )@€€€餒 ??  饞(??  養 S  ?V5_Toc375311130 OLE_LINK10 baidusnap0_GoBack1+?W51+?W5)%BCGilBZ]vy"CDph')+^_ceh  2 5 @ ??????????T5W5Py  ????x0??????????????55552565T5W5BCwxBCKLUV  ZZkltt#$klrs{{|| v"v"5%5%??=&>&A&B& ( (??????**e*f*?? + +++??????",#,??????//??????6070}0~0????011111 1 1p1q1u1v1x1y1z1{1????????????????????k2l2n2o2p2r2??????3333?????????????????????55552585Q5T5W5甞q甞q勮剺勮`剺(.勅刓勅`刓)刲刓刲`刓. 刓 `刓.劥 刓劥 `刓)刋 刓刋 `刓.匋刓匋`刓.劆刓劆`刓)凞刓凞`刓.甞q詘辇??'m搉U32'?  Bg ?p蔓塅X}?mT頵譖躾e}纩"H唃,IB(?iK !VO!怮!鋃@B;E齁G褆I鬑J疧JvuM?O鬋OTM2V?V%FVfV紉VIDMuRd??@(V5XX XNUnknown G*郃x Times New Roman5€Symbol3. *郈x Arial;= €鷟?褳SOSimHeiE5  N媅_GB2312甠o徟栄AE 筫ck\h媅€{SO甠o徟栄A5  wiSO_GB2312wiSO?E 筫ckN媅€{SO甠o徟栄;?媅SOSimSunA?$BCambria Math!h怢|'碩|G-`-`-!),.:;?]}    & 6"0000 0 000000  =@\]^?([{  0 0 00000;[??i個r??3僸HP??萡2! xx@\裇噀_7h  Xtzj.UserAdministrator ?鄥燆鵒h珣+'迟0€  0 < HT`hpx（局发文式样） Xtzj.UserNormalAdministrator4Microsoft Office Word@R烬@X?駱@0e@菵貵-?胀諟.摋+,0 X`t|  Xtzj.Com`?   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWX?Z[\]^_`?bcdefghijklmnopqrstuv?xyz{|}~?€??????Root Entry F+溘GData Y1Tablea?WordDocument <SummaryInformation(wDocumentSummaryInformation8MsoDataStore 第跥燖阚GQCFGCAXEYE0GQ==2 第跥燖阚GItem  PropertiesUCompObj e? ? ? ?  F#Microsoft Office Word 97-2003 文档 MSWordDoc?瞦