KRAS p.A146T Reference Standard
CBP10698
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| Introduction | |
| Format | Genomic DNA |
| Description | KRAS A146T is an exon four mutation that does not lie within any known functional domains of the Kras protein (UniProt.org). A146T decreases Kras GTPase activity, increases phosphorylation of Mek and Erk, and is transforming in cell culture and xenografts (PMID: 19075190, PMID: 20570890). |
| Technical Data | |
| DNA Change | c.436G>A |
| AA Change | p.A146T |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | NM_033360.4 |
| Cosmic ID | COSM19404 |
| Chr position(GRCh37) | chr12:25378562 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
