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免疫治疗

背景

 免疫治疗是指应用免疫学的原理和方法,通过调节免疫细胞的功能来达到治疗疾病的方法。目前的免疫治疗主要针对两大类疾病,一类是肿瘤相关的免疫治疗,主要是通过将免疫细胞或效应分子输入体内,增强或抑制某些免疫相关靶点来提高肿瘤细胞的免疫原性和对应效应细胞杀伤的敏感性激发和增强机体抗肿瘤免疫应答,从而协同机体免疫系统杀伤肿瘤,抑制肿瘤生长,是一种相对安全,长效,广谱的肿瘤治疗方法;另一类则主要针对自身免疫相关疾病的治疗靶点,通过开发抑制这些靶点功能的相关药物,降低机体异常的免疫反应水平,从而达到缓解自身免疫疾病的目的。

免疫治疗

      为满足针对免疫治疗靶点药物的研发,公海赌赌船官网jc710为您提供一系列相关靶点的细胞筛选模型,如IL12/4-1BB/ERBB3/CD28/PD1等,助力免疫治疗药物的开发。

分类  靶点  名称  货号
Fc Effector  ADCC/ADCP  ADCC Bioassay Effector Cell F variant (Low Affinity)- Fcγ-NFAT/Jurkat  CBP74002
 ADCC/ADCP  ADCC Bioassay Effector Cell V variant (High Affinity)-Fcγ-NFAT/Jurkat  CBP74003
 ADCC/ADCP  Mouse ADCC Bioassay Effector Cell  CBP74076
 ADCC/ADCP  ADCP Bioassay Effector Cell FcγRIa -NFAT/Jurkat  CBP74105
 ADCC/ADCP  ADCP Bioassay Effector Cell FcγRIIa (H variant) -NFAT/Jurkat  CBP74106
 ADCC/ADCP  ADCP Bioassay Effector Cell FcγRIIa (R variant) -NFAT/Jurkat  CBP74004
T Cell Activation  FcγR  FCGR2A/HEK293  CBP74077
 FcγR  FCGR2A(FcγRIIa)/CHO  CBP74074
 FcγR  FCGR2B/HEK293  CBP74078
 FcγR  FCGR2B(FcγRIIb)/CHO  CBP74075
 FcγR  FCGR2B/TCR Activator/CHO  CBP74096
 FcγR  hFGFR2b Effector Reporter Cell  CBP74196
 FcγR  mouse FCGR2B/CHO  CBP74100
 FcγR  mouse FCGR2B/TCR Activator/CHO  CBP74101
 FcγR  FCγR aAPC Cell  CBP74185
 N/A  TCR Activator/CHO  CBP74050
 N/A  TCR Activator/Raji  CBP74015
 N/A  NFAT-Luc/Jurkat  CBP74025
 N/A  FOXP3 promoter-Luc/Jurkat  CBP74011
 N/A  IL2 promoter-Luc/Jurkat  CBP74014
 N/A  NFκB-Luc/Jurkat  CBP74031
Immune Checkpoint  BDCA2  BDCA2 Effector Reporter Cell  CBP74226
 VSIG4  VSIG4/CHO  CBP74234
 CD200-CD200R  CD200R Effector Reporter cell  CBP74179
 CD200-CD200R  CD200 Target cell  CBP74180
 CD24  CD24/HEK293  CBP74191
Co-Stimulatory  4-1BB  41BB/NFκB-Luc/Jurkat  CBP74062
 4-1BB  41BB/NFκB-Luc/HEK293  CBP74045
 4-1BB  41BB/HEK293  CBP74040
 4-1BB  41BB/CHO  CBP74093
 BCMA  BCMA/NFκB-Luc/HEK293  CBP74072
 CD27-CD70  CD27/NFκB-Luc/Jurkat  CBP74007
 CD27-CD70  CD70/CHO  CBP74008
 CD27-CD70  CD27/HEK293  CBP74039
 CD27-CD70  CD27/CHO  CBP74033
 CD28-CD80/86  CD28 Effector Reporter Cell  CBP74099
 CD28-CD80/86  CD28 Effector Reporter-2 Cell  CBP74104
 CD28-CD80/86  CD80/CHO  CBP74069
 CD28-CD80/86  CD86/CHO  CBP74070
 CD40  CD40/NFκB-Luc/HEK293  CBP74009
 CD40  CD40/HEK293  CBP74041
 CD40  CD40/CHO  CBP74034
 DR3-TL1A  DR3 Effector Reporter Cell  CBP74236
 DR3-TL1A  TL1A Target Cell  CBP74252
 DR3-TL1A  TL1A CHO  CBP74251
 GITR-GITRL  GITR/NFκB-Luc/Jurkat  CBP74012
 GITR-GITRL  GITR/CHO  CBP74036
 GITR-GITRL  GITRL/CHO  CBP74094
 ICOS-ICOSL  ICOS Effector Reporter Cell  CBP74063
 ICOS-ICOSL  ICOSL/CHO  CBP74068
 MICA  MICA/CHO  CBP74184
 NCR1  NCR1(NKp46) Effector Reporter Cell  CBP74220
 NCR3  NCR3(NKp30) Effector Reporter Cell  CBP74239
 NKG2D  NKG2D Effector Reporter Cell  CBP74222
 OX40  OX40/NFκB-Luc/Jurkat  CBP74061
 OX40  OX40/NFκB-Luc/HEK293  CBP74017
 OX40  OX40/HEK293  CBP74049
 OX40  OX40/CHO  CBP74038
 TMIGD2-HHLA2  HHLA2(B7H7) aAPC Cell  CBP74194
 LTBR  LTBR Effector Reporter Cell  CBP74259
 TREM1  TREM1 Effector Reporter Cell  CBP74204
 TREM2  TREM2 Effector Reporter Cell  CBP74232
 TACI  hTACI Effector Reporter Cell  CBP74219
Co-Inhibitory  B7H3  4ig-B7H3(CD276)/CHO  CBP74141
 B7H3  4ig-B7H3(CD276)/THP-1  CBP75062
 BTLA-HVEM-LIGHT  BTLA Effector Reporter Cell  CBP74118
 BTLA-HVEM-LIGHT  BTLA/SHP2 Reporter Cell  CBP74177
 BTLA-HVEM-LIGHT  HVEM/U2OS Cell  CBP74178
 BTLA-HVEM-LIGHT  HVEM/TCR Activator/CHO  CBP74082
 BTLA-HVEM-LIGHT  HVEM/NFκB-Luc/Jurkat  CBP74013
 BTLA-HVEM-LIGHT  HVEM/HEK293  CBP74047
 BTLA-HVEM-LIGHT  HVEM/CHO  CBP74037
 BTLA-HVEM-LIGHT  LIGHT/CHO  CBP74029
 CD161-CLEC2D  CD161 Effector Reporter Cell  CBP74137
 CD161-CLEC2D  CLEC2D aAPC Cell  CBP74138
 CTLA4  CTLA4/ IL-2 promoter Reporter/Jurkat  CBP74084
 CTLA4  CTLA4/HEK293  CBP74046
 CTLA4  CTLA4/CHO  CBP74035
 HLA-G  B2M-associated HLA-G/aAPC Cell  CBP74189
 HLA-G  B2M-free HLA-G/aAPC Cell  CBP74190
 KIR3DL3-HHLA2  KIR3DL3 Effector Reporter Cell  CBP74193
 KIR3DL3-HHLA2  TMIGD2 Effector Reporter Cell  CBP74202
 LAG3  LAG3/NFAT-Luc/Jurkat  CBP74060
 LAG3  LAG3/IL-2-Luc/Jurkat  CBP74079
 LAG3  LAG3/HEK293  CBP74051
 LAG3  LAG3/CHO  CBP74052
 LILRB1  LILRB1 Effector Reporter Cell  CBP74187
 LILRB2  LILRB2 Effector Reporter Cell  CBP74188
 LILRB4  LILRB4 Effector Reporter Cell  CBP74102
 LILRB4  APOE/TCR Activator/CHO  CBP74107
 LILRB4  ANGPTLx/TCR Activator/CHO  CBP74103
 NKG2A-HLA-E  NKG2A Effector Reporter Cell  CBP74241
 NKG2A-HLA-E  HLA-E aAPC Cell  CBP74242
 PD1-PDL1/2  PDL1/HEK293  CBP74001
 PD1-PDL1/2  PD1/NFAT-Luc/Jurkat  CBP74018
 PD1-PDL1/2  PDL1/CHO  CBP74032
 PD1-PDL1/2  PD1/HEK293  CBP74042
 PD1-PDL1/2  PD1/CHO  CBP74043
 PD1-PDL1/2  PDL2/CHO  CBP74064
 PD1-PDL1/2  PDL2/TCR Activator/CHO  CBP74065
 PD1-PDL1/2  PDL1/TCR Activator/CHO  CBP74066
 PD1-PDL1/2  PDL1/Raji  CBP74095
 PD1-PDL1/2  PD1-IL2 Pathway Effector Reporter Cell  CBP74144
 PD1-PDL1/2  PDL1/aAPC/Raji  CBP74145
 PD1-PDL1/2  PD1/SHP2 Reporter Cell  CBP74224
 PD1-PDL1/2  PD1/SHP1 Reporter cell  CBP74231
 PD1-PDL1/2  PDL1 Target Cell(Suspension)  CBP74237
 PD1-PDL1/2  PDL1 Target Cell (Adherent)  CBP74240
 PD1-PDL1/2  PDL1 A549  CBP74245
 PVRIG-CD112  PVRIG(CD112R) Effector Reporter Cell  CBP74120
 PVRIG-CD112  CD112/TCR Activator/CHO  CBP74121
 SIRPɑ-CD47  SIRPɑ Effector Reporter Cell  CBP74122
 SIRPɑ-CD47  CD47+ Target Cell  CBP74124
 TIGIT-CD155  TIGIT/NFAT-Luc/Jurkat  CBP74020
 TIGIT-CD155  CD155/TCR Activator/CHO  CBP74073
 TIGIT-CD155  CD155/CHO  CBP74067
 TIM-3  TIM-3 Effector Reporter Cell  CBP74112
 TIM-3  TIM-3 Target cell  CBP74238
 N/A  PD1&CTLA4 Dual Effector Reporter Cell  CBP74150
 N/A  PDL1 CD80&CD86 aAPC Cell  CBP74151
 N/A  PD1&TIGIT Dual Effector Reporter Cell  CBP74126
 N/A  PDL1&CD155 TCR Activator CHO  CBP74127
 N/A  PD1&LAG3 Dual Effector Reporter Cell  CBP74147
 N/A  PDL1 MHCII APC Cell  CBP74146
 N/A  PD1&41BB Dual Effector Reporter Cell  CBP74172
 N/A  PD1&OX40 Dual Effector Reporter Cell  CBP74163
 N/A  PDL1 aAPC Cell  CBP74164
 N/A  SIRPα&CD47 Dual Effector Reporter Cell  CBP74123
 N/A  SIRPɑ&PD1 Dual Effector Reporter Cell  CBP74154
 N/A  CD47&PDL1 Dual Target Cell  CBP74155
 N/A  TIGIT&PVRIG Dual Effector Reporter Cell  CBP74167
 N/A  CD155&CD112 Dual aAPC Cell  CBP74168
Cytokine&Growth Factor  Activin  Activin A Effector Reporter Cell  CBP74225
 Activin  ACVR2A CHO  CBP74248
 Activin  ACVR2B CHO  CBP74249
 BNP/NPR1  BNP/NPR1 Effector Reporter Cells  CBP74198
 CSF1R  CSF1R/SRE-Luc/HEK293  CBP74010
 CSF1R  CSF1R/HEK293  CBP74048
 EGF  SRE-Luc/HEK293  CBP74030
 EPO  hEPO Effector Reporter Cell  CBP74169
 FGF21/KLB  KLB Effector Reporter Cell  CBP74209
 GDF  hGDF/GFRAL&RET Effector Reporter Cell  CBP74186
 GHR  hGHR Effector Reporter Cell  CBP74203
 GM-CSF  hGM-CSF Effector Reporter Cell  CBP74149
 IFN  ISRE-Luc/HEK293  CBPB0005
 IFN  ISRE-Luc/THP-1  CBPB0015
 IFN  GAS-Luc/THP-1  CBPB0014
 IL1  IL1 Effector Reporter Cell  CBP74253
 IL10  IL10 Effector Reporter Cell  CBP74158
 IL11  hIL11 Effector Reporter Cell  CBP74114
 IL12  IL12 Effector Reporter Cell  CBP74134
 IL18  hIL18 Effector Reporter Cell  CBP74173
 IL2/IL15  hIL2/IL15 Dual Effector(hCD122/hCD132) Reporter Cell  CBP74170
 IL2/IL15  hIL2/IL15 Dual Effector(hCD25/hCD122/hCD132) Reporter Cell  CBP74192
 IL2/IL15  hIL2/IL15 Dual Effector (mCD25/hCD122/mCD132) Reporter Cell  CBP74109
 IL21  hIL21 Effector Reporter Cell  CBP74183
 IL22  IL22 Effector Reporter Cell  CBP74175
 IL22  hIL19 IL20 IL24 Triple Effector Reporter Cell  CBP74223
 IL22  hIL20 IL22 IL24 Triple Effector Reporter Cell  CBP74228
 IL23  IL23 Effector Reporter Cell  CBP74130
 IL27  IL27 Effector Reporter Cell  CBP74199
 IL31  IL31 Effector Reporter Cell  CBP74159
 IL31  Canine IL31 Effector Reporter Cell  CBP74235
 IL33  hIL33 Effector Reporter Cell  CBP74176
 IL36  IL36 Effector Reporter Cell  CBP74119
 IL4/IL13  hIL4/IL13 Dual Effector Reporter Cell  CBP74110
 IL5  hIL5 Effector Reporter Cell  CBP74182
 IL7  hIL7 Effector Reporter Cell  CBP74221
 IL9  hIL9 Effector Reporter Cell  CBP74207
 KDR  VEGF(KDR) Effector Reporter Cell  CBP74162
 NGF  NGF/hTRKA Effector Reporter Cell  CBP74174
 NGF  NGF/Canine TRKA Effector Reporter Cell  CBP74230
 OSMR  OSMR Effector Reporter Cell  CBP74157
 PRL  hPRL Effector Reporter Cell  CBP74227
 RANK-RANKL  RANK Effector Reporter Cell  CBP74125
 RANK-RANKL  Membrane Anchored hRANKL Cell  CBP74160
 TIE2  TIE2/HEK293  CBP74161
 TNFα  Membrane Anchored TNFα Cell (Adherent)  CBP74152
 TNFα  Membrane Anchored TNFα Cell (Suspended)  CBP74153
 TPO  TPO Effector Reporter Cell  CBP74165
 TPOR  TPOR(Ligand Dependent)/BaF3  CBP73266
 TSLP  TSLPR/IL7R/BaF3  CBP74136
 TSLP  hTSLP Effector Reporter Cell  CBP74171
 VEGF  Membrane Anchored VEGF Cell  CBP74156
 WNT  Wnt Effector Reporter Cell  CBP74166
 WNT  SOST Effector Reporter Cell  CBP74247
 WNT  DKK1 Effector Reporter Cell  CBP74200
 WNT  DDR1 CHO  CBP74256
TAA  5T4  5T4 CHO  CBP74261
 CEACAM5  CEACAM5 CHO  CBP74257
 CLDN6  hClaudin 6(CLDN6)/CHO  CBP74181
 CLDN18.2  Claudin18.2/AGS  CBP74131
 CLDN18.2  Claudin18.2/CHO  CBP74139
 CLDN18.2  Claudin18.2/ HGC27  CBP74133
 CLDN18.2  Claudin18.2/ KATOIII  CBP74132
 CLDN18.2  Claudin18.2/Miapaca2  CBP74142
 CLDN18.2  Claudin18.2/NCI-N87  CBP74148
 CLDN18.2  Claudin18.2/NUGC4  CBP74135
 CLDN18.2  Claudin18.2/PANC-1  CBP74143
 DLL3  DLL3 CHO  CBP74254
 ERBB2  ERBB2 CHO  CBP74246
 ERBB3  hERBB3(HER3)/CHO  CBP75069
 ERBB3  ERBB3(HER3)/MDA-MB-231  CBP73348
 ERBB4  ERBB4/CHO  CBP73316
 FAP  FAP CHO  CBP74255
 FGFR1  FGFR1/HEK293  CBP75067
 FGFR2  FGFR2C/HEK293  CBP75066
 GPC3  GPC3 CHO  CBP74243
 LRRC15  LRRC15 CHO  CBP74250
 MERTK  mouse MERTK/CHO  CBP73398
 Notch1  Notch1/HEK293  CBP75052
 Nectin4  hNectin4/PC-3  CBP74205
 PSMA  PSMA/22RV1  CBP74210
 PSMA  PSMA/PC-3  CBP74206
 ROR1  hROR1/CHO  CBPG0100
 TF  TF CHO  CBP75078
TLR  TLR2  TLR2/NFκB-Luc/HEK293  CBP74113
 TLR3  TLR3/NFκB-Luc/HEK293  CBP74057
 TLR4  TLR4/NFκB-Luc/HEK293  CBP74128
 TLR5  TLR5/NFκB-Luc/HEK293  CBP74053
 TLR7  TLR7/NFκB-Luc/HEK293  CBP74090
 TLR8  TLR8/NFκB-Luc/HEK293  CBP74021
 TLR9  TLR9/NFκB-Luc/HEK293  CBP74091
STING  N/A  ISRE-Luc/NFκB-SEAP/THP-1  CBP74097
 N/A  ISRE-Luc/Raw264.7  CBP74098
 N/A  IRF5-KO/NFκB-SEAP/THP-1  CBP74212
 N/A  cGAS-KO/NFκB-SEAP/THP-1  CBP74214
 N/A  TREX1-KO/NFκB-SEAP/THP-1  CBP74215
 N/A  H232-hSTING-KI/NFκB-SEAP /THP-1  CBP74216
 N/A  R232-hSTING-KI/NFκB-SEAP/THP-1  CBP74217
 N/A  S154-hSTING-KI/NFκB-SEAP/THP-1  CBP74218

 

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