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tTMB-P4(21.09) Reference Standard

CBP80001-4

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I. Background

Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials.

 

Sample ID

Cat.No.

Background

Assay

Comments

DC198N0163

CBP80001-4N

B lymphoblast, male

500x WES

Same individual

 

DC198N0162

CBP80001-4T

Lung large cell carcinoma, male

500x WES

IDT xGenExome Research Panel v1.0捕获,Target Region 39M, Probe Region 51M, CDS Region 33.52M;
HiSeq X-TEN,af选择0.02 cut off,再过滤。
DC198N0162 is 100% Tumor sample.

 

 

Cut off =2%

Cut off =3%

Cut off =4%

Cut off =5%

Mutation Number

707

698

691

688

TMB value

21.09

20.82

20.61

20.53 

 

计算数据下载:DC198N0162.tmb

 
 
 
 
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