OVCAR3（人卵巢腺癌细胞）
CBP60294
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| I. General information | |
| Synonyms: | OVCAR3 |
| Background: | The NIH:OVCAR-3 line was established in 1982 by T.C. Hamilton, et al. from the malignant ascites of a patient with progressive adenocarcinoma of the ovary. |
| Species: | Homo sapiens, human |
| Tissue: | ovary |
| Disease: | adenocarcinoma |
| Gender: | female, 60 years, Caucasian |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| DNA Profile: | Amelogenin: X CSF1PO: 11,12 D13S317: 12 D16S539: 12 D5S818: 11,12 D7S820: 10 THO1: 9,9.3 TPOX: 8 vWA: 17 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+20%FBS+10ug/ml insulin OVCAR3完全培养基，# CBP60294M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Receptor Expression: | Androgen receptor, positive; estrogen receptor, positive; progesterone receptor, positive |
| Tumor Formation: | Yes, Forms colonies in soft agar Yes, in nude mice inoculated subcutaneously with 10(7) cells (Tumors developed within 21 days at 100% frequency (5/5).) |
| Comments: | Forms colonies in soft agar and has an abnormal karyotype. Resistant to clinically relevant concentrations of adriamycin, melphalan and cisplatin. Both cultured cells and xenografts exhibit androgen and estrogen receptors. Xenograft models have been used to show that treatment with 17 beta estradiol can induce progesterone receptors in this human ovarian carcinoma. For more information, please contact Cobioer (4008-750-250). |
