KRAS p.Q61K Reference Standard
CBP10302
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| Introduction | |
| Format | Genomic DNA |
| Description | KRAS Q61K is a hotspot mutation that lies within a GTP binding region of the Kras protein (UniProt.org). Q61K has not been characterized, but can be predicted to confer a loss of function on Kras protein based on the effects of HRAS Q61K, which results in decreased Hras GTPase activity and leads to transFormation of cells in culture (PMID: 3510078). |
| Technical Data | |
| DNA Change | c.181C>A |
| AA Change | p.Q61K |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 93.78% |
| Transcript | ENST00000311936 |
| Cosmic ID | COSM549 |
| Chr position(GRCh37) | chr12:25380277 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
