KRAS p.Q61L Reference Standard
CBP10303
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| Introduction | |
| Format | Genomic DNA |
| Description | KRAS Q61L is a hotspot mutation that lies within a GTP binding region of the Kras protein (UniProt.org). Q61L results in increased activation of ERK and is transforming in cell culture (PMID: 26854029) and therefore, is predicted to result in decreased Kras protein function. |
| Technical Data | |
| DNA Change | c.182A>T |
| AA Change | p.Q61L |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 66.67% |
| Transcript | ENST00000311936 |
| Cosmic ID | COSM553 |
| Chr position(GRCh37) | chr12:25380276 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
