U-2932（人B细胞淋巴瘤）
CBP60625
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| I. General information | |
| Synonyms: | U-2932 |
| Background: | established in 1996 from the ascites of a 29-year-old woman with diffuse large B cell lymphoma, who 16 years earlier was diagnosed with advanced stage Hodgkin lymphoma, and relapsed several times after multiple chemo- and radiotharapy regimens to complete remissions; cells were described in the literature to overexpress BCL2, BCL6 and p53; assigned to ABC-like lymphoma subtype (activated B-cell) |
| Species: | human (Homo sapiens) |
| Tissue: | N/A |
| Disease: | B cell lymphoma |
| Gender: | N/A |
| Morphology: | small round cells growing singly and in clusters in suspension; |
| Growth Mode: | N/A |
| Doubling Time: | ca. 50 hours |
| DNA Profile: | N/A Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+10%FBS U-2932完全培养基，# CBP60625M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Mycoplasma: | negative in microbiological culture, PCR assays |
| Immunology: | CD3 -, CD10 +, CD13 -, CD19 +, CD20 +, CD37 +, CD38 +, cyCD79a +, CD80 +, CD138 +, HLA-DR +, sm/cyIgG -, sm/cyIgM +, sm/cykappa +, sm/cylambda -; |
| Fingerprint: | fluorescent nonaplex PCR of short tandem repeat markers revealed a unique DNA profile |
| Species: | confirmed as human by species PCR |
| Cytogenetics: | human polyclonal hypodiploid karyotype with 20% polyploidy; 45(43-46)<2n>, XX, add(X)(q22), add(1)(q24), der(3)ins(3;18)(q27;q2?q2?)hsr(18)(q21), add(5)(q32), der(6)t(6;18)(p24;?q23)del(6)(q13), der(10)t(10;14)(q24;q23), der(11)t(1;11)(q25;q2?), der(14)t(3;14)(q27;p11), der(18)t(1;18)(q21;q21), der(18)t(3;18)(q2?;q27), add(19)(p13), del(19)(q13); sdl with del(2)(q11), t(4;15)(q22;q14), add(7)(q21), del(13)(?q21), der(13)add(13)(p11)add(13)(q32); extensive genomic amplification of BCL2 region; resembles published karyotype |
| Virus | PCR: EBV -, HBV -, HCV -, HIV-1 -, HIV-2 -, HTLV-I/II -, MLV -, SMRV - |
| Comments: | For more information, please contact Cobioer (4008-750-250). |
