OCI-LY3（人B细胞淋巴瘤）
CBP60265
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| I. General information | |
| Synonyms: | OCI-LY3 |
| Background: | established in 1983 from the bone marrow sample of a 52-year-old man with B-cell non-Hodgkin lymphoma (B-NHL, diffuse large B-cell lymphoma, DLBCL, stage 4B) at relapse; cells were described in the literature to be EBV-negative and lacking a classical t(8;14) translocation |
| Species: | human (Homo sapiens) |
| Tissue: | N/A |
| Disease: | B cell lymphoma |
| Gender: | N/A |
| Morphology: | round cells growing singly or in clumps in suspension; |
| Growth Mode: | N/A |
| Doubling Time: | ca. 24 hours |
| DNA Profile: | N/A Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
IMDM+ 20% FBS+0.05 mM 2-mercaptoethanol OCI-LY3完全培养基，# CBP60265M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Mycoplasma: | negative in PCR assay |
| Immunology: | CD3 -, CD10 -, CD13 -, CD19 -, CD20 +, CD34 -, CD37 +, CD38 +, cyCD79a +, CD80 +, CD138 -, HLA-DR +, sm/cyIgG +, sm/cyIgM -, sm/cykappa -, sm/cylambda +; in the referenced paper this cell line is described as CD19 +, cykappa +; image |
| Fingerprint: | genetic typing showed a pattern of short tandem repeats (STR) matching the reference profile of the international STR database |
| Species: | N/A |
| Cytogenetics: | human flat-moded hypertriploid karyotype; 72-77<3n>XXYY, +1, +9, -10, +13, +14, -17, +19, +20, +22, der(1)t(1;17)(p13;q12)x2, der(4)t(4;18)(q31;q21)x2, del(6)(q13)x2, der(6)t(6;6)(p24;q12), der(7)t(6;7)(p24;p22), der(14)t(14;19)(q32;q13.3)x2, del(18)(q21), der(19)t(4;19)(q21;q13)t(4;18)(q31;q21)x2, der(19)t(14;19), dup(20)(q11q13)x2; sdl with der(6)t(6;12)(p21;q21), der(7)t(5;7)(?p15;p24) etc; resembles published karyotypes; carries cryptic t(14;19) with rearrangement of IGH and SPIB, and t(4;18) with copy number amplification of the BCL2 region |
| Virus | PCR: HBV -, HCV -, HIV-1 -, HIV-2 -, MLV - |
| Comments: | For more information, please contact Cobioer (4008-750-250). |
