AI-Edigene® EGFR p.E746_A750delELREA Reference Standard Plus
CBP10418
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索取COA
产品描述
产品数据库
| Introduction | |
| Format | Genomic DNA |
| Description | EGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750. E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth in xenograft models, and is transforming in cell culture. |
| Technical Data | |
| DNA Change | c.2236_2250del15 GAATTAAGAGAAGCA>- |
| AA Change | p.E746_A750delELREA |
| Mutation type | Deletion - In frame |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000275493 |
| Cosmic ID | COSM6225 |
| Chr position(GRCh37) | chr7:55242466_55242480 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
