背景
机体具有完善精密的免疫调节和免疫监视功能,当肿瘤细胞侵袭时,免疫系统可以识别肿瘤细胞表面的肿瘤特异性抗原 (Tumour-associated antigens,TAAs),激活特异性体液免疫应答和细胞免疫应答,清除入侵的肿瘤细胞;同时,肿瘤细胞也能够通过多种途径负向调节机体免疫应答,逃逸机体免疫监管,在肿瘤免疫治疗的领域,从早期的细胞因子的发现,到免疫检查点抑制剂,单克隆抗体、双特异性抗体的飞速发展,包括细胞治疗、溶瘤病毒、肿瘤疫苗等方法的出现,免疫疗法改变了传统肿瘤治疗的方式,为癌症患者提供无限可能。
TAA Mouse Model介绍
肿瘤免疫治疗领域的研究依然火热,针对各靶点公海赌赌船官网jc710开发了几百种报告基因的细胞模型,以及一百多种现货人源靶点的小鼠细胞模型如下表所示,目前我们已经在4T1/CT26/MC-38 等常见的鼠源细胞上进行了改造,将人源的热门免疫靶点通过基因手段,稳定表达在细胞上。
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4T1 |
A20 |
ANA-1 |
B16-F10 |
C1498 |
CT26 |
EL4 |
EMT6 |
H22 |
Hepa 1-6 |
ID8 |
KLN205 |
LL/2 |
MC-38 |
MFC |
PANC02 |
RENCA |
RM1 |
5T4 |
· |
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· |
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· |
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B7H3 |
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· |
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· |
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· |
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B7H4 |
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· |
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· |
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BCMA |
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CD123 |
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CD138 |
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CD19 |
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CD20 |
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· |
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· |
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CD22 |
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CD24 |
· |
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CD30 |
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CD33 |
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· |
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CD38 |
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CD70 |
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CD73 |
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CD74 |
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CD79 |
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CDH17 |
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CDH3 |
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· |
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CDH6 |
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· |
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· |
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CEACAM5 |
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Claudin18.2 |
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· |
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· |
· |
· |
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Claudin9 |
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Claudin6 |
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CLEC12A |
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DDR1 |
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DLL3 |
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· |
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· |
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· |
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EGFR |
· |
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· |
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· |
· |
· |
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EGFR&ERBB3 |
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ERBB2 |
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· |
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ERBB3(HER3) |
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EpCAM |
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FAP |
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FOLR1 |
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GPC3 |
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GPRC5D |
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GUCY2C |
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IL2R |
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KK-LC-1 |
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LILRB4 |
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LRRC15 |
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LY6G6D |
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MET |
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MSLN |
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· |
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· |
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MUC16 |
· |
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Nectin4 |
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· |
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· |
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· |
OVA |
· |
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· |
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· |
· |
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· |
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· |
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· |
PDL1 |
· |
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· |
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· |
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· |
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· |
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PSMA |
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PTK7 |
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ROR1 |
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SSTR2 |
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TF |
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TFRC |
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TROP2 |
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