TP53 p.H214R Reference Standard
CBP10215
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| Introduction | |
| Format | Genomic DNA |
| Description | TP53 H214R lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). H214R results in increased IL-6 expression and colony Formation compared to wild-type Tp53 in cell culture (PMID: 11920959), and is therefore predicted to confer a gain of function to Tp53. |
| Technical Data | |
| DNA Change | c.641A>G |
| AA Change | p.H214R |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 35.47% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM43687 |
| Chr position(GRCh37) | chr17:7578208 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
