528 Gene PLus TMB Panel

CBPF0003

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528 Gene Plus TMB Panel
Descripition	此实体瘤泛癌种Panel包含下列528个基因的全部编码区，30个常见实体瘤的融合基因热点内含子区域，99个微卫星不稳定检测位点，覆盖基因组约1.37Mb区域，支持包括碱基替换、插入、缺失检测分析。

528个基因：含全部外显子区域
ABL1	IKBKE	STK11	GATA2	RPS6KA4	ERCC1	POLD1	CREBBP	NOTCH2
CBL	MERTK	ALOX12B	INSR	TCF3	GNAS	RYBP	ETV1	PRDM14
DUSP4	PDGFRB	CD70	MSH3	ARID2	KDM5A	TMEM127	HDAC1	SETD2
FH	RASA1	ELOC	PIK3CB	CDK8	MYD88	AXIN1	KMT2A	TRAF7
IFNGR1	STAG2	FUBP1	RICTOR	EPHB4	PMAIP1	CHEK1	NFKBIA	BCL2
MDM4	AKT1	INHBA	SYK	GLI1	RRAS2	ERF	PPP2R2A	CSF3R
PBRM1	CCNQ	MLH1	ARAF	JAK1	TET2	GSK3B	SDHD	FAM46C
RAD52	EIF1AX	PIK3C2B	CDH1	MUTYH	ATR	KEL	TP53	HIST1H3B
SPOP	FOXA1	REL	EPHA3	PIK3R3	CDKN2C	NEGR1	BAP1	KNSTRN
ABRAXAS1	IKZF1	STK19	GATA3	RPS6KB2	ERCC2	POLE	CRKL	NOTCH3
CCND1	MET	AMER1	IRF2	TCF7L2	GPS2	SDHA	ETV6	PREX2
E2F3	PDK1	CD79A	MSH6	ARID5B	KDM5C	TMPRSS2	HGF	SF3B1
FLCN	RB1	EMSY	PIK3CD	CDKN1A	MYOD1	AXIN2	KMT2B	TSC1
IGF1	STAT3	FYN	RIT1	ERBB2	PMS1	CHEK2	NKX2-1	BCL2L1
MED12	AKT2	INPP4A	TAP1	GNA11	RTEL1	ERG	PPP4R2	CTCF
PDCD1	CD22	MPL	ARFRP1	JAK2	TGFBR1	H3F3A	SESN1	FANCA
RAD54L	EIF4A2	PIK3C2G	CDK12	MYC	ATRX	KIT	TP53BP1	HIST1H3C
SPRED1	FOXL2	RET	EPHA5	PIM1	CEBPA	NF1	BARD1	KRAS
ACVR1	IL10	STK40	GATA4	RPTOR	ERCC3	PPARG	CRLF2	NOTCH4
CCND2	MGA	ANKRD11	IRF4	TEK	GREM1	SDHAF2	EZH1	PRKAR1A
EED	PDPK1	CD79B	MST1R	ASXL1	KDM6A	TNFAIP3	HIST1H1C	SGK1
FLT1	RBM10	EP300	PIK3CG	CDKN1B	NBN	AXL	KMT2C	TSC2
IGF1R	STAT5A	GABRA6	RNF43	ERBB3	PMS2	CIC	NKX3-1	BCL2L11
MEF2B	AKT3	INPP4B	TAP2	GNA13	RUNX1	ERRFI1	PPP6C	CTLA4
PDCD1LG2	CD274	MRE11	ARID1A	JAK3	TGFBR2	H3F3B	SESN2	FANCC
RAF1	EIF4E	PIK3C3	CDK4	MYCL	AURKA	KLF4	TP63	HIST1H3D
SRC	FOXO1	RHEB	EPHA7	PLCG2	CENPA	NF2	BBC3	LATS1
ACVR1B	IL7R	SUFU	GATA6	RRAGC	ERCC4	PPM1D	CSDE1	NPM1
CCND3	MITF	APC	IRS1	TERT	GRIN2A	SDHB	EZH2	PRKCI
EGFL7	PGR	CDC42	MTAP	ASXL2	KDR	TNFRSF14	HIST1H2BD	SH2B3
FLT3	RECQL	EPAS1	PIK3R1	CDKN2A	NCOA3	B2M	KMT2D	TSHR
IGF2	STAT5B	GATA1	ROS1	ERBB4	PNRC1	COP1	NOTCH1	BCL2L2
MEN1	ALK	INPPL1	TBX3	GNAQ	RXRA	ESR1	PRDM1	CTNNA1
PDGFRA	CD276	MSH2	ARID1B	JUN	TIPARP	H3F3C	SESN3	FANCD2
RARA	ELF3	PIK3CA	CDK6	MYCN	AURKB	KLHL6	TRAF2	HIST1H3E
SRSF2	FOXP1	RHOA	EPHB1	PLK2	CHD4	NFE2L2	BCL10	LATS2
AGO2	INHA	SUZ12	GID4	RRAS	ERCC5	PPP2R1A	CSF1R	NRAS
CCNE1	MKNK1	AR	IRS2	TET1	GRM3	SDHC	EZR	PRKD1
EGFR	PHOX2B	CDC73	MTOR	ATM	KEAP1	TOP1	HIST1H3A	SH2D1A
FLT4	RECQL4	EPCAM	PIK3R2	CDKN2B	NCOR1	BABAM1	KMT5A	TYRO3
BCL6	CUL4A	FAS	HIST2H3D	MAP2K4	P2RY8	RAC2	SOX10	CASP8
CTNNB1	FANCG	HIST1H3J	MAP2K1	NUF2	RAB35	SOCS1	ZNF217	DOT1L
FANCE	HIST1H3H	MAF	NTRK2	PTPRT	SMYD3	YES1	CARD11	FGFR3
HIST1H3F	LTK	NTHL1	PTPRO	SMARCD1	XRCC2	BTK	DNMT3A	IDH1
LMO1	NSD3	PTPN11	SMARCA4	XIAP	BTG1	DNAJB1	FGFR1	MDC1
NSD1	PTEN	SMAD3	WT1	BRD4	DICER1	FGF4	ICOSLG	PARP3
PRKN	SLX4	VTCN1	BRCA1	DDR1	FGF23	HSD3B1	MAX	RAD51C
SHOC2	VEGFA	BMPR1A	DAXX	FGF14	HOXB13	MAPK3	PARP1	SOX9
U2AF1	BIRC3	CYP17A1	FGF10	HLA-B	MAP3K14	PAK5	RAD51	CBFB
BCOR	CXCR4	FAT1	HIST3H3	MAP3K1	PAK1	RAD21	SOX17	DROSHA
CUL3	FANCL	HIST2H3C	MAP2K2	NUP93	RAC1	SOS1	ZNF703	FGFR4
FANCF	HIST1H3I	MALT1	NTRK3	QKI	SNCAIP	ZFHX3	CARM1	IDH2
HIST1H3G	LYN	NTRK1	PTPRS	SMO	YAP1	CALR	DNMT3B	MDM2
LRP1B	NT5C2	PTPRD	SMARCB1	XPO1	BTG2	DNMT1	FGFR2	PAX5
NSD2	PTP4A1	SMAD4	WWTR1	BRIP1	DIS3	FGF6	ID3	RAD51D
PTCH1	SMAD2	WISP3	BRCA2	DDR2	FGF3	HSP90AA1	MCL1	SPEN
SHQ1	VHL	BRAF	DCUN1D1	FGF19	HRAS	MAPKAP1	PARP2
UPF1	BLM	CYSLTR2	FGF12	HNF1A	MAPK1	PALB2	RAD51B
BCORL1	CYLD	FBXW7	HLA-A	MAP3K13	PAK3	RAD50	SOX2

30个融合基因区域：部分内含子区域
基因	区域			基因		区域
ALK	intron:17;18;19;20;21			KMT2A		intron:6;7;8;9;10;11
BCR	intron:8;13;14			MET		intron:14
BRAF	intron:7;8;9;10			MYC		intron:1
BRCA1	intron:2;7;8;12;16;19;20			NOTCH2		intron:26
BRCA2	intron:2			NTRK1		intron:6;7;8;9
CD74	UTR;intron:6;7;8			NTRK2		intron:12;15
ETV4	intron:5;6			NUTM1		intron:1
ETV5	intron:6;7			PDGFRA		intron:7;9;11
ETV6	intron:5;6			RAF1		intron:4;5;6;7;8;9
EWSR1	intron:6;7;8;9;10;11;12;13			RARA		intron:
EZR	intron:10;11;12			RET		intron:6;7;8;9;10;11
FGFR1	intron:1;5			ROS1		intron:32;33;34;35
FGFR2	intron:1;17			SDC4		intron:2
FGFR3	intron14;16;17			SLC34A2		intron:4
KIT	intron:16			TMPRSS2		intron:1;2;3

99个微卫星不稳定位点
BAT26	2B3D NCI Panel(CSCO指南);Promega Panel
BAT25	2B3D NCI Panel(CSCO指南);Promega Panel
D5S346	2B3D NCI Panel(CSCO指南)
D2S123	2B3D NCI Panel(CSCO指南)
D17S250	2B3D NCI Panel(CSCO指南)
NR21	Promega Panel
NR24	Promega Panel
NR27	Promega Panel
MONO27	Promega Panel
MSI:10-99	额外已验证的89个微卫星位点

Product Information
Intended Use	Research Use Only
Unit Size	96 rxn
Storage	-25 ~ -15°C
Expiry	12 months from the date of manufacture