ICOSL/CHO
CBP74068
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| I. Background | |
| ICOSL is the Ligand for the T-cell-specific cell surface receptor ICOS. When engaged by the ICOSL, the ICOS initiates a costimulatory signal for T-cell proliferation and cytokine production. It also induces B-cell proliferation and differentiation into plasma cells. The ICOS/ICOSL is a major regulator of the adaptive immune responses and also plays an important role in mediating local tissue responses to inflammatory conditions. | |
| II. Description | |
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Recombinant CHO-K1 cells constitutively expressing human ICOSL (also known as human secreted B7 homolog 2 (B7-H2), CD275, ICOSLG, and B7-related protein (B7RP), GenBank Accession No. NM_001283050. |
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| III. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | ICOSL |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | B7 homolog 2, CD275, ICOSL, ICOSLG, B7-related protein (B7RP), B7-H2 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12k+10%FBS+500ug/ml Hygromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Ligand of ICOS&Binding Assay,FACS |
| IV. Description of Host Cell Line | |
| Organism: | Cricetulus griseus, hamster, Chinese |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
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Figure 1.Recombinant CHO-cells constitutively expressing human ICOSL. |
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