c-Kit V559A/BaF3
CBP73286
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| I. Introduction | |
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Cell Line Name： |
c-Kit V559A/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Anti-proliferation assay and PD assay |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| II. Background | |
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KIT V559A lies within the juxtamembrane domain (exon 11) of the Kit protein (PMID: 15837988). V559A results in constitutive phosphorylation of Kit and increased Mapk and Akt activation in patient samples and cultured cells (PMID: 15837988, PMID: 19047099). |
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| III. Representative Data | |
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1.Sanger of c-Kit V559A/BaF3
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2. Anti-proliferation assay
Figure 2. CTG Proliferation Assay of BaF3 c-KIT V559A (C2). |
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