CFPAC-1（人胰腺导管腺癌细胞）
CBP60665
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| I. General information | |
| Synonyms: | CFPAC-1 |
| Species: | Homo sapiens, human |
| Tissue: | pancreas; derived from metastatic: liver |
| Disease: | ductal adenocarcinoma; cystic fibrosis |
| Gender: | Caucasian,male,26 years |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| Doubling Time: | 32 hrs |
| DNA Profile: | Amelogenin: X,Y CSF1PO: 10 D13S317: 12 D16S539: 9,11 D5S818: 10,11 D7S820: 8,10 THO1: 8 TPOX: 8 vWA: 17 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
IMDM+10%FBS CFPAC-1完全培养基，# CBP60665M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | Culture medium, 95%; DMSO, 5% |
| Tumor Formation: | Yes, in nude mice，Yes, in the cheek pouch of cortisone treated hamsters |
| Comments: | The cells exhibit ion transport activities consistent with cystic fibrosis and express the product of the CF gene (cystic fibrosis transmembrane regulator, CFTR).CFPAC-1 cells show no effect of cAMP agonists, adenyl cyclase stimulators or phosphodiesterase inhibitors on Cl- flux, but do respond to Ca++ ionophores with increase Cl- efflux. The cells have the most common form of the CF mutation, deletion of three nucleotides resulting in the absence of phenylalanine at position 508.CFPAC-1 cells have epithelial morphology and polarization with apical microvilli, tight junctions and gap junctions. For more information, please contact Cobioer (4008-750-250). |
