TP53 p.G245C Reference Standard

CBP10154

询价

索取COA

产品描述

产品数据库

Introduction
Format	Genomic DNA
Description	TP53 G245C is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245C results in a loss of transactivation of several targets of wild-type Tp53 (PMID: 22170099, PMID: 30126368), and also confers a gain-of-function to Tp53, as demonstrated through inhibition of Ampk activation in cell culture, and leads to increased tumor Formation in mouse models (PMID: 24857548), and increased migration and invasion in culture (PMID: 30126368).

Technical Data
DNA Change:	c.733G>T
AA Change	p.G245C
Mutation type	Substitution - Missense
Zygosity	Homozygous
Allelic Frequency	100%
Transcript	ENST00000269305
Cosmic ID	COSM11081
Chr position(GRCh37)	chr17:7577548
Buffer:	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing
Storage	2-8℃
Expiry	36 months from the date of manufacture

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