TP53 p.G245D Reference Standard

CBP10153

询价

索取COA

产品描述

产品数据库

Introduction
Format	Genomic DNA
Description	TP53 G245D is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245D results in decreased activation of Tp53 target genes (PMID: 22214764, PMID: 25634208, PMID: 27533082), and also confers a gain-of-function to Tp53 as demonstrated by aberrant interaction with ZBP-89, as well as induction of FOXM1 expression, and leads to decreased apoptosis in culture and increased tumor growth and metastasis in mouse models (PMID: 22214764, PMID: 29269868).

Technical Data
DNA Change:	c.734G>A
AA Change	p.G245D
Mutation type	Substitution - Missense
Zygosity	Homozygous
Allelic Frequency	100%
Transcript	ENST00000269305
Cosmic ID	COSM43606
Chr position(GRCh37)	chr17:7577547
Buffer:	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing	Download for COA
Storage	2-8℃
Expiry	36 months from the date of manufacture

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