HCC1569（人乳腺癌细胞）
CBP60372
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| I. General information | |
| Synonyms: | HCC1569 |
| Background: | The cell line is derived from an older patient with a germline mutation in the FHIT gene. The FHIT gene is located at 3p14.2 and the mutation is a transversion at nucleotide 651 (G to T).The patient's daughter carries the same gene mutation. This cell line was initiated on 3/8/95 and took 19 months to establish. |
| Species: | Homo sapiens, human |
| Tissue: | mammary gland; breast |
| Disease: | TNM stage IV, grade 3, primary metaplastic carcinoma |
| Gender: | female, 70 years, Black |
| Morphology: | epithelial |
| Growth Mode: | mixed adherent-suspension |
| Culture Medium: |
RPMI-1640+20%FBS HCC1569完全培养基，# CBP60372M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Receptor Expression: | estrogen receptor, negative progesterone receptor, negative |
| Oncogene: | her2/neu +, p53 - |
| Genes Expressed: | Epithelial glycoprotein 2 [EGP2]; cytokeratin 19 |
| Cellular Products: | Epithelial glycoprotein 2 [EGP2]; cytokeratin 19 |
| Comments: | The patient received prior chemotherapy and had no family history of breast cancer. The tumor was classified as TNM stage IV, grade 3, metaplastic carcinoma with 4 out of 18 lymph node metastasis. The cells are poorly differentiated. The cells are positive for expression of Her2-neu and negative for expression of p53. HCC1569 is positive for the epithelial cell specific marker Epithelial Glycoprotein 2 (EGP2) and for cytokeratin 19. The cells are negative for expression of estrogen receptor (ER) and for expression of progesterone receptor (PR) by immunohistochemistry, but PR expression was detectable at a low level by cytosolic protein assay. For more information, please contact Cobioer (4008-750-250). |
