HCC70（人乳腺癌细胞）
CBP60375
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| I. General information | |
| Synonyms: | HCC70 |
| Background: | The HCC70 cell line was initiated from a primary ductal carcinoma on June 3, 1992, and took 44 months to establish. |
| Species: | Homo sapiens, human |
| Tissue: | breast; mammary gland/duct |
| Disease: | TNM stage IIIA, grade 3, primary ductal carcinoma |
| Gender: | female, 49 years, Black |
| Morphology: | epithelial |
| Growth Mode: | adherent, The line grows as attached medium-sized epithelial cells. |
| DNA Profile: | Amelogenin:X CSF1PO:10,14 D13S317:12 D16S539:9,13 D5S818:12,13 D7S820:10,11 THO1:9 TPOX:10 vWA: 13,15 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+10%FBS HCC70完全培养基，# CBP60375M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Receptor Expression: | progesterone receptor, not expressed |
| Oncogene: | her2/neu -, p53 + (overexpressed) |
| Genes Expressed: | Epithelial glycoprotein 2 [EGP2]; cytokeratin 19 |
| Cellular Products: | Epithelial glycoprotein 2 [EGP2]; cytokeratin 19 |
| Comments: | The cells are poorly differentiated. The tumor was classified as TNM Stage IIIA, grade 3, invasive ductal carcinoma with metastases in 4 out of 17 lymph nodes. The cells overexpress p53, and are negative for the expression of Her2-neu oncogenes. HCC70 is positive for the epithelial cell specific marker Epithelial Glycoprotein 2 (EGP2) and for cytokeratin 19 The depositor of ATCC CRL-2315 initially reported the cells were positive for estrogen receptors. However, recent studies performed outside of ATCC have given conflicting results about the status of the estrogen receptor for these cells. An independent study at ATCC confirmed that ATCC CRL-2315, HCC70, is ER negative, PR negative and Her2 negative. For more information, please contact Cobioer (4008-750-250). |
