MDA-MB-468（人乳腺癌细胞）
CBP60387
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| I. General information | |
| Synonyms: | MDA-MB-468 |
| Background: | The MDA-MB-468 cell line was isolated in 1977 by R. Cailleau, et al., from a pleural effusion of a 51-year-old Black female patient with metastatic adenocarcinoma of the breast. |
| Species: | Homo sapiens, human |
| Tissue: | mammary gland/breast; derived from metastatic site: pleural effusion |
| Disease: | adenocarcinoma |
| Gender: | female, 51 years, Black |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| Doubling Time: | N/A |
| DNA Profile: | Amelogenin: X CSF1PO: 12 D13S317: 12 D16S539: 9 D5S818: 12 D7S820: 8 THO1: 7 TPOX: 8,9 vWA: 18 Cobioer’s Cell Line Authentication Service |
| Isoenzymes | AK-1, 1 ES-D, 1 G6PD, A GLO-I, 1-2 Me-2, 1-2 PGM1, 1 PGM3, 2 |
| Culture Medium: |
DMEM+ 10% FBS MDA-MB-468完全培养基，# CBP60387M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | Blood Type AB; HLA Aw23, Aw30, B27, Bw35, Cw2, Cw4 (patient) |
| Receptor Expression: | epidermal growth factor (EGF); transforming growth factor alpha (TGF alpha) |
| Oncogene: | N/A |
| Genes Expressed: | N/A |
| Cellular Products: | N/A |
| Tumor Formation: | Yes, in nude mice inoculated subcutaneously with 10(7) cells. (Tumors developed within 21 days at 100% frequency (5/5).) |
| Comments: | Although the tissue donor was heterozygous for the G6PD alleles, the cell line consistently showed only the G6PD A phenotype. There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution. EGF receptor is present at 1 X 106 per cell. For more information, please contact Cobioer (4008-750-250). |
