JVM-2（人EB病毒感染的套细胞外周淋巴瘤细胞）
CBP60820
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| I. General information | |
| Synonyms: | JVM-2 |
| Background: | Leukemic cells from a patient with B-prolymphocytic leukemia were immortalized in vitro with Epstein-Barr virus (EBV) in the presence of phorbol-ester, TPA. |
| Species: | Homo sapiens, human |
| Tissue: | peripheral blood |
| Disease: | Mantle Cell Lymphoma |
| Gender: | female, 63 years, Caucasian |
| Morphology: | lymphoblast |
| Growth Mode: | suspension |
| Doubling Time: | about 48 hours |
| DNA Profile: | Amelogenin: X CSF1PO: 11 D13S317: 11,13 D16S539: 12,13 D5S818: 11,12 D7S820: 10,11 THO1: 6,9 TPOX: 8,11 vWA: 17 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+10%FBS JVM-2完全培养基，# CBP60820M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | CD3-, CD5-, CD10-, CD19+, CD20+, CD23+ (verified at ATCC) |
| Oncogene: | p53 [PubMed: 16434365] |
| Genes Expressed: | p53 Ref,CD3-, CD5-, CD10-, CD19+, CD20+, CD23+ (verified at ATCC) |
| Comments: | JVM-2 is characterized cytogenetically by t(11;14)(q13; q32) Ref Ref. JVM-2 cells retain p16 expression and exhibit low expression of cyclin D1. This cell line expresses cyclin D2 Ref. Based on the new classification of lymphomas, JVM-2 is considered a Mantle Cell Lymphoma (MCL) Ref Ref . For more information, please contact Cobioer (4008-750-250). |
