Panc 10.05（人胰腺腺癌细胞）
CBP60846
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| I. General information | |
| Synonyms: | Panc 10.05 |
| Background: | Panc 10.05 is a pancreatic adenocarcinoma epithelial cell line derived in 1992 from a primary tumor removed from the head-of-the-pancreas of a male with pancreatic adenocarcinoma. The Panc 10.05 cell line was derived from the same patient as the PL45 cell line (ATCC CRL-2558). |
| Species: | Homo sapiens, human |
| Tissue: | pancreas |
| Disease: | adenocarcinoma |
| Gender: | male, adult, Caucasian |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| Doubling Time: | 19.2 hrs |
| DNA Profile: | D5S818: 13 D13S317: 12 D7S820: 8,9 D16S539: 9,12 vWA: 16 THO1: 6,9.3 Amelogenin: X TPOX: 11 CSF1PO: 12 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+15%FBS+10ug/ml insulin Panc 10.05完全培养基，# CBP60846M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | MHC class I +; MHC class II - |
| Receptor Expression: | |
| Oncogene: | K-ras + Ref |
| Genes Expressed: | cytokeratins 7 and 18 Ref |
| Cellular Products: | cytokeratins 7 and 18 Ref |
| Tumor Formation: | Yes, forms tumors in nude or SCID mice |
| Comments: | Both the PL45 and the Panc 10.05 cell lines exhibit a K-ras oncogene mutation at codon 12 where a GGT --> GAT mutation resulted in substitution of aspartic acid for glycine. The cells have a reported plating efficiency of 40%. For more information, please contact Cobioer (4008-750-250). |
