TP53 p.P151S Reference Standard
CBP10185
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| Introduction | |
| Format | Genomic DNA |
| Description | TP53 P151S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). P151S results in a loss of Tp53 transactivation activity and resistance to anoikis in cell culture, and promotes tumor growth in xenograft models (PMID: 21903770, PMID: 23625637). |
| Technical Data | |
| DNA Change | c.451C>T |
| AA Change | p.P151S |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10905 |
| Chr position(GRCh37) | chr17:7578479 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
