TP53 p.P278S Reference Standard

CBP10200

询价

索取COA

产品描述

产品数据库

Introduction
Format	Genomic DNA
Description	TP53 P278S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). P278S results in the loss of Tp53 transactivation of p21, while retaining activation of Axl in cell culture, and promotes tumor growth in xenograft models (PMID: 22989750), and in mouse cells harboring the equivalent mouse variant (P275S), results in decreased activation of Tp53 target genes and reduced apoptotic response following DNA damage (PMID: 11867759).

Technical Data
DNA Change	c.832C>T
AA Change	p.P278S
Mutation type	Substitution - Missense
Zygosity	Homozygous
Allelic Frequency	100%
Transcript	ENST00000269305
Cosmic ID	COSM10939
Chr position(GRCh37)	chr17:7577106
Buffer	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing	Download for COA
Storage	2-8℃
Expiry	36 months from the date of manufacture

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