TP53 p.R280K Reference Standard
CBP10186
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| Introduction | |
| Format | Genomic DNA |
| Description | TP53 R280K lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R280K results in decreased activation and repression of wild-type Tp53 target genes (PMID: 17070499, PMID: 16322760, PMID: 18472962), as well as a gain-of-function in activation of novel targets, and leads to increased cell migration and invasion, and increased cell survival (PMID: 18472962, PMID: 24763051). |
| Technical Data | |
| DNA Change | c.839G>A |
| AA Change | p.R280K |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10728 |
| Chr position(GRCh37) | chr17:7577099 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
