PDL1 MHCII APC Cell
CBP74146
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| I. Background | |
| Programmed Cell Death Protein 1 (PD-1),一种在激活的 T 细胞上表达的受体，与其配体 PD-L1 和 PD-L2 结合，负向调节免疫反应。 PD-1 配体存在于大多数癌症中，PD-1:PD-L1/2 相互作用会抑制 T 细胞活性，并使癌细胞逃避免疫监视。 PD1/PDL1信号转导通路是肿瘤免疫抑制的重要组成部分，可以抑制T淋巴细胞的兴奋，增强肿瘤细胞的免疫耐受，从而实现肿瘤免疫逃逸。 | |
| II. Introduction | |
| Expressed gene: | PD-L1、MHCII |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
Figure 1. RecombinantPDL1/MHCII APC Cell constitutively expressing PDL1.
Figure 2. Dose Response of Blocking Antibodies in PD-1/LAG3 Dual Effector Reporter Cells (C15) With PD-L1/MHCII APC Cells.
