hGDF/GFRAL&RET Effector Reporter Cell
CBP74186
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| I. Background | |
| GFRAL是GDF15的受体，GDF15通过与GFRAL结合发挥作用，GFRAL在结合 GDF15 后与辅助受体RET结合形成GDF15-GFRAL-RET complex复合物，激活下游AKT, ERK and PLC-ϒ信号通路。 | |
| II. Introduction | |
| Host Cell: | N/A |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2ug/ml puromycin+200ug/ml hygromycin+10ug/ml blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
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Figure 1. Recombinant hGDF/GFRAL&RET Effector Reporter Cell constitutively expressing GFRAL. |
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Figure 2. Recombinant hGDF/GFRAL&RET Effector Reporter Cell constitutively expressing RET. |
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Figure 3.Dose Response of Recombinant Human GDF-15 in hGDF/GFRAL&RET Effector Reporter Cells (C1). |
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Figure 4.Inhibition of hGDF-15-induced Reporter Activity by hGDF-15 Neutralization Ab in GDF-15/hGFRAL&Ret Effector Reporter Cell (Clone1). |
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