HCC1428（人乳腺腺癌细胞）
CBP60412
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| I. General information | |
| Synonyms: | HCC1428 |
| Background: | HCC1428 was derived from a female who harbored a homozygous deletion in the FHIT gene. This cell line was initiated on 11/4/95 and took 15 months to establish. |
| Species: | Homo sapiens, human |
| Tissue: | mammary gland/breast; derived from metastatic site: adenocarcinoma and pleural effusion |
| Disease: | TNM stage IV, grade 4, adenocarcinoma |
| Gender: | Caucasian, White, 49 years, female |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| Doubling Time: | N/A |
| DNA Profile: | CSF1PO: 10 D13S317: 12 D16S539: 12,8 D5S818: 11,12 D7S820: 9 THO1: 8 TPOX: 8 vWA: 17 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+10%FBS HCC1428完全培养基，# CBP60412M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | N/A |
| Receptor Expression: | N/A |
| Oncogene: | her2/neu -, p53 - |
| Genes Expressed: | HCC1428 cells are positive for the expression of Epithelial glycoprotein 2 [EGP2]; cytokeratin 19 The cells are negative for expression of Her2-neu and for expression of p53. |
| Cellular Products: | N/A |
| Tumor Formation: | N/A |
| Comments: | An EBV transformed lymphoblastoid cell line [HCC1428 BL] from the same patient is available as ATCC CRL-2328. The homozygous deletion in the FHIT gene is retained in the lymphoblastoid line. The FHIT gene, which spans the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene in breast and other cancers. For more information, please contact Cobioer (4008-750-250). |
