SK-BR-3（人乳腺腺癌细胞）
CBP60413
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| I. General information | |
| Synonyms: | SK-BR-3 |
| Background: | This cell line was derived by G. Trempe and L. J. Old in 1970 from pleural effusion cells of a patient, a White, Caucasian female, age 43, blood type A+, who had been treated with radiation, steroids, cytoxan and 5-fluorouracil. |
| Species: | Homo sapiens, human |
| Tissue: | mammary gland/breast; derived from metastatic site: pleural effusion |
| Disease: | adenocarcinoma |
| Gender: | female, Caucasian, 43 years |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| Doubling Time: | N/A |
| DNA Profile: | Amelogenin: X CSF1PO: 12 D13S317: 11,12 D16S539: 9 D5S818: 9,12 D7S820: 9,12 THO1: 8,9 TPOX: 8,11 vWA: 17 Cobioer’s Cell Line Authentication Service |
| Isoenzymes: | AK-1, 1-2 ES-D, 1 G6PD, B GLO-I, 2 PGM1, 1-2 PGM3, 1 |
| Culture Medium: |
McCoy's 5a+10%FBS SK-BR-3完全培养基，# CBP60413M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | Blood Type A; Rh+; HLA A11, Bw22(+/-), B40, B18 |
| Receptor Expression: | N/A |
| Oncogene: | N/A |
| Genes Expressed: | N/A |
| Cellular Products: | N/A |
| Tumor Formation: | Yes, in nude mice; forms poorly differentiated adenocarcinoma |
| Comments: | The patient, a White, Caucasian female, age 43, blood type A+, had been treated with radiation, steroids, cytoxan and 5-fluorouracil. No virus particles. Ultrastructural features include microvilli and desmosomes, glycogen granules, large lysosomes, bundles of cytoplasmic fibrils. The SK-BR-3 cell line overexpresses the HER2/c-erb-2 gene product. For more information, please contact Cobioer (4008-750-250). |
